AMM 376: Overcome Botox Resistance: Strategies and Insights with Xeomin
March 15, 2025
This episode tackles the issue of Botox resistance, a concern for those using neuromodulators in aesthetic medicine. Dr. Melissa K. Levin explains how antibody formation can reduce the effectiveness of treatments such as Botox over time. She discusses the importance of choosing the right type of neuromodulator and strategically planning treatment frequency to minimize resistance. Dr. Levin highlights Xeomin as having a lower likelihood of resistance compared to Botox Cosmetic or Dysport. Listeners will learn strategies for prevention and management of resistance, including switching brands or considering alternative therapies. The episode emphasizes the importance of working with a provider to explore personalized solutions while acknowledging the value of natural beauty.
Quick Takes
- Xeomin has a lower chance of causing resistance compared to Botox Cosmetic or Dysport.
- Clustering your treatments might decrease your chances of developing resistance.
- If resistance occurs, switching to another neuromodulator brand or alternative treatments may be necessary.
Episode Transcript
On March 4, 2025, we dive into a prevalent concern in aesthetic medicine: Botox resistance. Board-certified dermatologist Dr. Melissa K. Levin sheds light on what happens when the efficacy of Botox, and other neuromodulators, declines over time. The issue arises due to antibody formation that reduces the potency of these treatments. While it’s rare, it’s crucial to consider the type of neuromodulator and frequency of injections.
Levin notes that Xeomin has a lower chance of causing resistance compared to Botox Cosmetic or Dysport. As for prevention, it’s about strategy. Clustering your treatments might decrease your chances of developing resistance. If resistance does occur, switching to another neuromodulator brand or incorporating a “wash-out period” might be needed, or even considering alternative treatments like energy-based therapies. Always engage closely with your provider to find a personalized solution. Remember, sometimes embracing natural beauty isn’t so bad either. Until next time, stay curious and informed.
