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AMM 113: Radiesse vs Sculptra: New Study Reveals Key Differences
June 19, 2024
In this episode, we delve into a recent study comparing two popular regenerative fillers: CaHA (Radiesse) and PLLA-SCA (Sculptra). Listeners will learn about the significant morphological differences between these fillers and their implications for clinical use. The study reveals that while CaHA microspheres have a smooth and homogeneous structure, PLLA-SCA particles are highly variable in shape and size. This variability may influence the body’s immune response and impact the fillers’ overall effectiveness. Join us as we explore how understanding particle geometry can guide better product selection and patient outcomes.
Quick Takes
- The study examined the morphological differences between CaHA (Radiesse) and PLLA (Sculptra) fillers
- CaHA microspheres were smooth, homogeneous, and spherical with a diameter between 25 to 45 microns
- PLLA particles were irregularly shaped with a broad size range which may lead to a higher potential for causing an immune response
Episode Transcript
Today is June 19th, 2024. A recent study has examined the morphological differences between two popular types of regenerative fillers: CaHA (Radiesse) developed by Merz Aesthetics, and PLLA (Sculptra) from Galderma.
The study utilized advanced techniques like scanning electron microscopy (SEM) and brightfield microscopy to analyze the particle shapes, sizes, and their implications for clinical use. CaHA microspheres were found to be smooth, homogeneous, and predominantly spherical. These particles had a consistent diameter between 25 to 45 microns, demonstrating high circularity and roundness. The uniform shape of these particles might be linked to less inflammatory response in the body.
On the other hand, PLLA particles showed a lot of variability. These flakes were irregularly shaped with a broad size range, from 2 to 150 microns. This heterogeneity may suggest a higher potential for causing an immune response.
These differences might impact the fillers’ physiological effects. CaHA’s smooth particles are likely less inflammatory. In contrast, PLLA’s irregular shapes might provoke a macrophage-mediated biostimulatory pathway, potentially leading to more pronounced inflammatory responses.
Understanding these distinctions helps in selecting the right product based on patient needs and desired outcomes. This study also underscores the importance of particle geometry in biostimulators, shedding light on their interactions with the body’s immune system.
Stay tuned for more insights tomorrow!
